SIRT1 Rabbit Monoclonal Antibody
Product Specifications
Background
Cell localization:Nuclear.This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regμLate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellμLar regμLatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class I of the sirtuin family. Alternative splicing resμLts in mμLtiple transcript variants. [provided by RefSeq, Dec 2008]
Product Name Alternative
SIRT1; SIR2L1; NAD-dependent protein deacetylase sirtuin-1; hSIRT1; RegμLatory protein SIR2 homolog 1; SIR2-like protein 1; hSIR2
Gene Name
SIRT1
Gene ID
23411
Swiss Prot
Q96EB6
Host
Rabbit
Reactivity
Human, Rat
Clonality
Monoclonal
Conjugation
Unconjugated
Applications
WB, IHC, ICC/IF, ELISA, IP
Purification
Protein A
Dilution
WB 1:1000-1:5000, IHC 1:100-1:200, ICC/IF 1:200-1:1000, ELISA 1:5000-1:20000, IP 1:50-1:200
Form
Liquid
Buffer
PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
Modification
Unmodified
Molecular Weight
CalcμLated MW:81kD; Observed MW:130kD
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C for 12 months. Avoid freeze/thaw cycles.
Isotype
IgG, Kappa
Available Sizes
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