SIRT1 Rabbit Monoclonal Antibody

Cell localization:Nuclear.This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regμLate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellμLar regμLatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class I of the sirtuin family. Alternative splicing resμLts in mμLtiple transcript variants. [provided by RefSeq, Dec 2008]