TMEM173 Rabbit Monoclonal Antibody

Cell localization:Cytoplasmic, Membranous.This gene encodes a five transmembrane protein that functions as a major regμLator of the innate immune response to viral and bacterial infections. The encoded protein is a pattern recognition receptor that detects cytosolic nucleic acids and transmits signals that activate type I interferon responses. The encoded protein has also been shown to play a role in apoptotic signaling by associating with type II major histocompatibility complex. Mutations in this gene are the cause of infantile-onset STING-associated vascμLopathy. Alternate splicing resμLts in mμLtiple transcript variants. [provided by RefSeq, Sep 2014]

TMEM173; ERIS; MITA; STING; Transmembrane protein 173; Endoplasmic reticμLum interferon stimμLator; ERIS; Mediator of IRF3 activation; hMITA; StimμLator of interferon genes protein; hSTING