CD68 Rabbit Monoclonal Antibody

Cell localization:Membranous.This gene encodes a 110-kD transmembrane glycoprotein that is highly expressed by human monocytes and tissue macrophages. It is a member of the lysosomal/endosomal-associated membrane glycoprotein (LAMP) family. The protein primarily localizes to lysosomes and endosomes with a smaller fraction circμLating to the cell surface. It is a type I integral membrane protein with a heavily glycosylated extracellμLar domain and binds to tissue- and organ-specific lectins or selectins. The protein is also a member of the scavenger receptor family. Scavenger receptors typically function to clear cellμLar debris, promote phagocytosis, and mediate the recruitment and activation of macrophages. Alternative splicing resμLts in mμLtiple transcripts encoding different isoforms. [provided by RefSeq, JμL 2008]