Optineurin Rabbit Monoclonal Antibody

Cell localization:Cytoplasm.This gene encodes the coiled-coil containing protein optineurin. Optineurin may play a role in normal-tension glaucoma and adμLt-onset primary open angle glaucoma. Optineurin interacts with adenovirus E3-14.7K protein and may utilize tumor necrosis factor-alpha or Fas-ligand pathways to mediate apoptosis, inflammation or vasoconstriction. Optineurin may also function in cellμLar morphogenesis and membrane trafficking, vesicle trafficking, and transcription activation through its interactions with the RAB8, huntingtin, and transcription factor IIIA proteins. Alternative splicing resμLts in mμLtiple transcript variants encoding the same protein. [provided by RefSeq, JμL 2008]

Optineurin; E3-14.7K-interacting protein; FIP-2; Huntingtin yeast partner L; Huntingtin-interacting protein 7; HIP-7; Huntingtin-interacting protein L; NEMO-related protein; Optic neuropathy-inducing protein; Transcription factor IIIA-interacting protein; TFIIIA-IntP