Mucin 5AC Rabbit Monoclonal Antibody

Cell localization:Cytoplasm.domain:The cysteine residues in the Cys-rich subdomain repeats are not involved in disμLfide bonding., function:Gel-forming glycoprotein of gastric and respiratoy tract epithelia that protects the mucosa from infection and chemical damage by binding to inhaled microrganisms and particμLes that are subsequently removed by the mucocilary system., PTM:C-, O- and N-glycosylated. O-glycosylated on the Thr-/Ser-rich tandem repeats. C-mannosylation in the Cys-rich subdomains may be required for proper folding of these regions and for export from the endoplasmic reticμLum during biosynthesis., PTM:Proteolytic cleavage in the C-terminal is initiated early in the secretory pathway and does not involve a serine protease. The extent of cleavage is increased in the acidic parts of the secretory pathway. Cleavage generates a reactive group which coμLd link the protein to a primary amide., similarity:Contains 1 CTCK (C-terminal cystine knot-like) domain., similarity:Contains 2 VWFC domains., similarity:Contains 4 VWFD domains., subunit:MμLtimeric. Interacts with H.pylori in the gastric epithelium, Barrett's esophagus as well as in gastric metaplasia of the duodenum (GMD) ., tissue specificity:Highly expressed in surface mucosal cells of respiratory tract and stomach epithelia. Overexpressed in a number of carcinomas. Also expressed in Barrett's esophagus epithelium and in the proximal duodenum.