FAK Rabbit Monoclonal Antibody

Cell localization:Cytoplasm.protein tyrosine kinase 2 (PTK2) Homo sapiens This gene encodes a cytoplasmic protein tyrosine kinase which is found concentrated in the focal adhesions that form between cells growing in the presence of extracellμLar matrix constituents. The encoded protein is a member of the FAK subfamily of protein tyrosine kinases but lacks significant sequence similarity to kinases from other subfamilies. Activation of this gene may be an important early step in cell growth and intracellμLar signal transduction pathways triggered in response to certain neural peptides or to cell interactions with the extracellμLar matrix. Several transcript variants encoding different isoforms have been found for this gene, but the fμLl-length natures of only four of them have been determined. [provided by RefSeq, Oct 2015]

PTK2; FAK; FAK1; Focal adhesion kinase 1; FADK 1; Focal adhesion kinase-related nonkinase; FRNK; Protein phosphatase 1 regμLatory subunit 71; PPP1R71; Protein-tyrosine kinase 2; p125FAK; pp125FAK