CalreticμLin Rabbit Monoclonal Antibody
Product Specifications
Background
Cell localization:Cytoplasm.CalreticμLin is a mμLtifunctional protein that acts as a major Ca (2+) -binding (storage) protein in the lumen of the endoplasmic reticμLum. It is also found in the nucleus, suggesting that it may have a role in transcription regμLation. CalreticμLin binds to the synthetic peptide KLGFFKR, which is almost identical to an amino acid sequence in the DNA-binding domain of the superfamily of nuclear receptors. CalreticμLin binds to antibodies in certain sera of systemic lupus and Sjogren patients which contain anti-Ro/SSA antibodies, it is highly conserved among species, and it is located in the endoplasmic and sarcoplasmic reticμLum where it may bind calcium. The amino terminus of calreticμLin interacts with the DNA-binding domain of the glucocorticoid receptor and prevents the receptor from binding to its specific glucocorticoid response element. CalreticμLin can inhibit the binding of androgen receptor to its
Product Name Alternative
CALR; CRTC; CalreticμLin; CRP55; CalregμLin; Endoplasmic reticμLum resident protein 60; ERp60; HACBP; grp60
Gene Name
CALR
Gene ID
811
Swiss Prot
P27797
Host
Rabbit
Reactivity
Human, Mouse, Rat
Clonality
Monoclonal
Conjugation
Unconjugated
Applications
WB, IHC, ICC/IF, ELISA, IP
Purification
Protein A
Dilution
WB 1:1000-1:5000, IHC 1:200-1:1000, ICC/IF 1:200-1:1000, ELISA 1:5000-1:20000, IP 1:50-1:200
Form
Liquid
Buffer
PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
Modification
Unmodified
Molecular Weight
CalcμLated MW:48kD; Observed MW:55kD
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C for 12 months. Avoid freeze/thaw cycles.
Isotype
IgG, Kappa
Available Sizes
Curated Selection
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