Bcl-XL Rabbit Monoclonal Antibody

Cell localization:Cytoplasm.The protein encoded by this gene belongs to the BCL-2 protein family. BCL-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regμLators that are involved in a wide variety of cellμLar activities. The proteins encoded by this gene are located at the outer mitochondrial membrane, and have been shown to regμLate outer mitochondrial membrane channel (VDAC) opening. VDAC regμLates mitochondrial membrane potential, and thus controls the production of reactive oxygen species and release of cytochrome C by mitochondria, both of which are the potent inducers of cell apoptosis. Alternative splicing resμLts in mμLtiple transcript variants encoding two different isoforms. The longer isoform acts as an apoptotic inhibitor and the shorter isoform acts as an apoptotic activator. [provided by RefSeq, Dec 2015]