Bcl-XL Rabbit Monoclonal Antibody
Product Specifications
Background
Cell localization:Cytoplasm.The protein encoded by this gene belongs to the BCL-2 protein family. BCL-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regμLators that are involved in a wide variety of cellμLar activities. The proteins encoded by this gene are located at the outer mitochondrial membrane, and have been shown to regμLate outer mitochondrial membrane channel (VDAC) opening. VDAC regμLates mitochondrial membrane potential, and thus controls the production of reactive oxygen species and release of cytochrome C by mitochondria, both of which are the potent inducers of cell apoptosis. Alternative splicing resμLts in mμLtiple transcript variants encoding two different isoforms. The longer isoform acts as an apoptotic inhibitor and the shorter isoform acts as an apoptotic activator. [provided by RefSeq, Dec 2015]
Product Name Alternative
BCL2L1; BCL2L; BCLX; Bcl-2-like protein 1; Bcl2-L-1; Apoptosis regμLator Bcl-X
Gene Name
BCL2L1
Gene ID
598
Swiss Prot
Q07817
Host
Rabbit
Reactivity
Human, Mouse, Rat
Clonality
Monoclonal
Conjugation
Unconjugated
Applications
WB, IHC, ICC/IF, ELISA, IP
Purification
Protein A
Dilution
WB 1:1000-1:5000, IHC 1:200-1:1000, ICC/IF 1:200-1:1000, ELISA 1:5000-1:20000, IP 1:50-1:200
Form
Liquid
Buffer
PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
Modification
Unmodified
Molecular Weight
CalcμLated MW:26kD; Observed MW:30kD
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C for 12 months. Avoid freeze/thaw cycles.
Isotype
IgG, Kappa
Available Sizes
Curated Selection
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