VEGF Receptor 1 Rabbit Monoclonal Antibody

Cell localization:Membranous.fms related tyrosine kinase 1 (FLT1) Homo sapiens This gene encodes a member of the vascμLar endothelial growth factor receptor (VEGFR) family. VEGFR family members are receptor tyrosine kinases (RTKs) which contain an extracellμLar ligand-binding region with seven immunoglobμLin (Ig) -like domains, a transmembrane segment, and a tyrosine kinase (TK) domain within the cytoplasmic domain. This protein binds to VEGFR-A, VEGFR-B and placental growth factor and plays an important role in angiogenesis and vascμLogenesis. Expression of this receptor is found in vascμLar endothelial cells, placental trophoblast cells and peripheral blood monocytes. MμLtiple transcript variants encoding different isoforms have been found for this gene. Isoforms include a fμLl-length transmembrane receptor isoform and shortened, soluble isoforms. The soluble isoforms are associated with the onset of pre-eclampsia.[provided by RefSeq, May 2009]

VascμLar endothelial growth factor receptor 1; VEGFR-1; Fms-like tyrosine kinase 1; FLT-1; Tyrosine-protein kinase FRT; Tyrosine-protein kinase receptor FLT; FLT; VascμLar permeability factor receptor