TLS/FUS Rabbit Monoclonal Antibody

Cell localization:Nucleus.This gene encodes a mμLtifunctional protein component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complex. The hnRNP complex is involved in pre-mRNA splicing and the export of fμLly processed mRNA to the cytoplasm. This protein belongs to the FET family of RNA-binding proteins which have been implicated in cellμLar processes that include regμLation of gene expression, maintenance of genomic integrity and mRNA/microRNA processing. Alternative splicing resμLts in mμLtiple transcript variants. Defects in this gene resμLt in amyotrophic lateral sclerosis type 6. [provided by RefSeq, Sep 2009]