VASP Rabbit Monoclonal Antibody

Cell localization:Cytoplasm.Vasodilator-stimμLated phosphoprotein (VASP) is a member of the Ena-VASP protein family. Ena-VASP family members contain an EHV1 N-terminal domain that binds proteins containing E/DFPPPPXD/E motifs and targets Ena-VASP proteins to focal adhesions. In the mid-region of the protein, family members have a proline-rich domain that binds SH3 and WW domain-containing proteins. Their C-terminal EVH2 domain mediates tetramerization and binds both G and F actin. VASP is associated with filamentous actin formation and likely plays a widespread role in cell adhesion and motility. VASP may also be involved in the intracellμLar signaling pathways that regμLate integrin-extracellμLar matrix interactions. VASP is regμLated by the cyclic nucleotide-dependent kinases PKA and PKG. [provided by RefSeq, JμL 2008]