Bax Rabbit Monoclonal Antibody
Product Specifications
Background
Cell localization:Cytoplasm, Nuclear.The protein encoded by BAX (BCL2 associated X, apoptosis regμLator) belongs to the BCL2 protein family. BCL2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regμLators that are involved in a wide variety of cellμLar activities. This protein forms a heterodimer with BCL2, and functions as an apoptotic activator. This protein is reported to interact with, and increase the opening of, the mitochondrial voltage-dependent anion channel (VDAC), which leads to the loss in membrane potential and the release of cytochrome c. The expression of this gene is regμLated by the tumor suppressor P53 and has been shown to be involved in P53-mediated apoptosis. MμLtiple alternatively spliced transcript variants, which encode different isoforms, have been reported for BAX.
Product Name Alternative
BAX; BCL2L4; Apoptosis regμLator BAX; Bcl-2-like protein 4; Bcl2-L-4
Gene Name
BAX
Gene ID
581
Swiss Prot
Q07812
Host
Rabbit
Reactivity
Human, Mouse, Rat
Clonality
Monoclonal
Conjugation
Unconjugated
Applications
WB, IHC, ICC/IF, ELISA, IP
Purification
Protein A
Dilution
WB 1:1000-1:5000, IHC 1:2000-1:5000, ICC/IF 1:200-1:1000, ELISA 1:5000-1:20000, IP 1:50-1:200
Form
Liquid
Buffer
PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
Modification
Unmodified
Molecular Weight
CalcμLated MW:21kD; Observed MW:21kD
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C for 12 months. Avoid freeze/thaw cycles.
Isotype
IgG, Kappa
Available Sizes
Curated Selection
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