TDP43 Rabbit Monoclonal Antibody

Cell localization:Nucleus.TAR DNA binding protein (TARDBP) Homo sapiens HIV-1, the causative agent of acquired immunodeficiency syndrome (AIDS), contains an RNA genome that produces a chromosomally integrated DNA during the replicative cycle. Activation of HIV-1 gene expression by the transactivator Tat is dependent on an RNA regμLatory element (TAR) located downstream of the transcription initiation site. The protein encoded by this gene is a transcriptional repressor that binds to chromosomally integrated TAR DNA and represses HIV-1 transcription. In addition, this protein regμLates alternate splicing of the CFTR gene. A similar pseudogene is present on chromosome 20. [provided by RefSeq, JμL 2008]