TGF β1/3 Rabbit Monoclonal Antibody

Cell localization:Secreted.This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regμLate gene expression. The encoded preproprotein is proteolytically processed to generate a latency-associated peptide (LAP) and a mature peptide, and is found in either a latent form composed of a mature peptide homodimer, a LAP homodimer, and a latent TGF-beta binding protein, or in an active form consisting solely of the mature peptide homodimer. The mature peptide may also form heterodimers with other TGF-beta family members. This protein is involved in embryogenesis and cell differentiation, and may play a role in wound healing. Mutations in this gene are a cause of aortic aneurysms and dissections, as well as familial arrhythmogenic

Transforming growth factor beta-1 proprotein; Latency-associated peptide; LAP; Transforming growth factor beta-1; TGF-beta-1; Transforming growth factor beta-3 proprotein; Transforming growth factor beta-3; TGF-beta-3