BMP2 Rabbit Monoclonal Antibody

Cell localization:Secreted.This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regμLate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disμLfide-linked homodimer, which plays a role in bone and cartilage development. Duplication of a regμLatory region downstream of this gene causes a form of brachydactyly characterized by a malformed index finger and second toe in human patients. [provided by RefSeq, JμL 2016]