β Catenin Rabbit Monoclonal Antibody
Product Specifications
Background
Cell localization:Cytoplasm, Membrane.The protein encoded by this gene is part of a complex of proteins that constitute adherens junctions (AJs) . AJs are necessary for the creation and maintenance of epithelial cell layers by regμLating cell growth and adhesion between cells. The encoded protein also anchors the actin cytoskeleton and may be responsible for transmitting the contact inhibition signal that causes cells to stop dividing once the epithelial sheet is complete. Finally, this protein binds to the product of the APC gene, which is mutated in adenomatous polyposis of the colon. Mutations in this gene are a cause of colorectal cancer (CRC), pilomatrixoma (PTR), medμLloblastoma (MDB), and ovarian cancer. Alternative splicing resμLts in mμLtiple transcript variants. [provided by RefSeq, Aug 2016]
Product Name Alternative
CTNNB1; CTNNB; OK/SW-cl.35; Catenin beta-1; Beta-catenin
Gene Name
CTNNB1 CTNNB OK/SW-cl.35 PRO2286
Gene ID
1499
Swiss Prot
P35222
Host
Rabbit
Reactivity
Human, Mouse, Rat
Clonality
Monoclonal
Conjugation
Unconjugated
Applications
WB, IHC, ICC/IF, ELISA, IP
Purification
Protein A
Dilution
WB 1:1000-1:5000, IHC 1:1000-1:5000, ICC/IF 1:200-1:1000, ELISA 1:5000-1:20000, IP 1:50-1:200
Form
Liquid
Buffer
PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
Modification
Unmodified
Molecular Weight
CalcμLated MW:84kD; Observed MW:96kD
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C for 12 months. Avoid freeze/thaw cycles.
Isotype
IgG, Kappa
Available Sizes
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