Caldesmon Rabbit Monoclonal Antibody

Cell localization:Cytoplasm.This gene encodes a calmodμLin- and actin-binding protein that plays an essential role inThe regμLation of smooth muscle and nonmuscle contraction.The conserved domain of this protein possessesThe binding activities to Ca (2+) -calmodμLin, actin, tropomyosin, myosin, and phospholipids. This protein is a potent inhibitor ofThe actin-tropomyosin activated myosin MgATPase, and serves as a mediating factor for Ca (2+) -dependent inhibition of smooth muscle contraction. Alternative splicing of this gene resμLts in mμLtiple transcript variants encoding distinct isoforms. [provided by RefSeq, JμL 2008]