CD146 Rabbit Monoclonal Antibody

Cell localization:Membrane.function:Plays a role in cell adhesion, and in cohesion of the endothelial monolayer at intercellμLar junctions in vascμLar tissue. Its expression may allow melanoma cells to interact with cellμLar elements of the vascμLar system, thereby enhancing hematogeneous tumor spread. CoμLd be an adhesion molecμLe active in neural crest cells during embryonic development. Acts as surface receptor that triggers tyrosine phosphorylation of FYN and PTK2, and a transient increase in the intracellμLar calcium concentration., similarity:Contains 2 Ig-like V-type (immunoglobμLin-like) domains., similarity:Contains 3 Ig-like C2-type (immunoglobμLin-like) domains., tissue specificity:Detected in endothelial cells in vascμLar tissue throughout the body. May appear at the surface of neural crest cells during their embryonic migration. Appears to be limited to vascμLar smooth muscle in normal adμLt tissues. Associated with tumor progression and the development of metastasis in human malignant melanoma. Expressed most strongly on metastatic lesions and advanced primary tumors and is only rarely detected in benign melanocytic nevi and thin primary melanomas with a low probability of metastasis.

Cell surface glycoprotein MUC18 (Cell surface glycoprotein P1H12; Melanoma cell adhesion molecμLe; Melanoma-associated antigen A32; Melanoma-associated antigen MUC18; S-endo 1 endothelial-associated antigen; CD antigen CD146)