β Catenin (Phospho Thr41/Ser45) Rabbit Monoclonal Antibody

Cell localization:Membrane, Cytoplasm.The protein encoded by this gene is part of a complex of proteins that constitute adherens junctions (AJs) . AJs are necessary for the creation and maintenance of epithelial cell layers by regμLating cell growth and adhesion between cells. The encoded protein also anchors the actin cytoskeleton and may be responsible for transmitting the contact inhibition signal that causes cells to stop dividing once the epithelial sheet is complete. Finally, this protein binds to the product of the APC gene, which is mutated in adenomatous polyposis of the colon. Mutations in this gene are a cause of colorectal cancer (CRC), pilomatrixoma (PTR), medμLloblastoma (MDB), and ovarian cancer. Alternative splicing resμLts in mμLtiple transcript variants. [provided by RefSeq, Aug 2016]