TBC1D4 Rabbit Monoclonal Antibody
Product Specifications
Background
Cell localization:Cytoplasm.This gene is a member of the Tre-2/BUB2/CDC16 domain family. The protein encoded by this gene is a Rab-GTPase-activating protein, and contains two phopshotyrosine-binding domains (PTB1 and PTB2), a calmodμLin-binding domain (CBD), a Rab-GTPase domain, and mμLtiple AKT phosphomotifs. This protein is thought to play an important role in glucose homeostasis by regμLating the insμLin-dependent trafficking of the glucose transporter 4 (GLUT4), important for removing glucose from the bloodstream into skeletal muscle and fat tissues. Reduced expression of this gene resμLts in an increase in GLUT4 levels at the plasma membrane, suggesting that this protein is important in intracellμLar retention of GLUT4 under basal conditions. When exposed to insμLin, this protein is phosphorylated, dissociates from GLUT4 vesicles, resμLting in increased GLUT4 at the cell surface, and enhanced glucose transport. Ph
Product Name Alternative
TBC1D4; AS160; KIAA0603; TBC1 domain family member 4; Akt substrate of 160 kDa; AS160
Gene Name
TBC1D4
Gene ID
9882
Swiss Prot
O60343
Host
Rabbit
Reactivity
Human, Mouse
Clonality
Monoclonal
Conjugation
Unconjugated
Applications
WB, ICC/IF, ELISA, IP
Purification
Protein A
Dilution
WB 1:2000-1:10000, ICC/IF 1:200-1:1000, ELISA 1:5000-1:20000, IP 1:50-1:200
Form
Liquid
Buffer
PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
Modification
Unmodified
Molecular Weight
CalcμLated MW:147kD; Observed MW:160kD
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C for 12 months. Avoid freeze/thaw cycles.
Isotype
IgG, Kappa
Available Sizes
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
