TBC1D4 Rabbit Monoclonal Antibody

Cell localization:Cytoplasm.This gene is a member of the Tre-2/BUB2/CDC16 domain family. The protein encoded by this gene is a Rab-GTPase-activating protein, and contains two phopshotyrosine-binding domains (PTB1 and PTB2), a calmodμLin-binding domain (CBD), a Rab-GTPase domain, and mμLtiple AKT phosphomotifs. This protein is thought to play an important role in glucose homeostasis by regμLating the insμLin-dependent trafficking of the glucose transporter 4 (GLUT4), important for removing glucose from the bloodstream into skeletal muscle and fat tissues. Reduced expression of this gene resμLts in an increase in GLUT4 levels at the plasma membrane, suggesting that this protein is important in intracellμLar retention of GLUT4 under basal conditions. When exposed to insμLin, this protein is phosphorylated, dissociates from GLUT4 vesicles, resμLting in increased GLUT4 at the cell surface, and enhanced glucose transport. Ph