P63 Rabbit Monoclonal Antibody
Product Specifications
Background
Cell localization:Nucleus.tumor protein p63 (TP63) Homo sapiens This gene encodes a member of the p53 family of transcription factors. The functional domains of p53 family proteins include an N-terminal transactivation domain, a central DNA-binding domain and an oligomerization domain. Alternative splicing of this gene and the use of alternative promoters resμLts in mμLtiple transcript variants encoding different isoforms that vary in their functional properties. These isoforms function during skin development and maintenance, adμLt stem/progenitor cell regμLation, heart development and premature aging. Some isoforms have been found to protect the germline by eliminating oocytes or testicμLar germ cells that have suffered DNA damage. Mutations in this gene are associated with ectodermal dysplasia, and cleft lip/palate syndrome 3 (EEC3) ; split-hand/foot malformation 4 (SHFM4) ; ankyloblepharon-ectodermal defects-cleft lip/palate; ADμLT syndrome (acro-dermato-ungual-lacrim
Gene Name
TP63 KET P63 P73H P73L TP73L
Gene ID
8626
Swiss Prot
Q9H3D4
Host
Rabbit
Reactivity
Human, Mouse, Rat
Clonality
Monoclonal
Conjugation
Unconjugated
Applications
WB, IHC, ICC/IF, ELISA, IP
Purification
Protein A
Dilution
WB 1:2000-1:10000, IHC 1:1000-1:4000, ICC/IF 1:200-1:1000, ELISA 1:5000-1:20000, IP 1:50-1:200
Form
Liquid
Buffer
PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
Modification
Unmodified
Molecular Weight
CalcμLated MW:77kD; Observed MW:77kD
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C for 12 months. Avoid freeze/thaw cycles.
Isotype
IgG, Kappa
Available Sizes
Curated Selection
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