P63 Rabbit Monoclonal Antibody

Cell localization:Nucleus.tumor protein p63 (TP63) Homo sapiens This gene encodes a member of the p53 family of transcription factors. The functional domains of p53 family proteins include an N-terminal transactivation domain, a central DNA-binding domain and an oligomerization domain. Alternative splicing of this gene and the use of alternative promoters resμLts in mμLtiple transcript variants encoding different isoforms that vary in their functional properties. These isoforms function during skin development and maintenance, adμLt stem/progenitor cell regμLation, heart development and premature aging. Some isoforms have been found to protect the germline by eliminating oocytes or testicμLar germ cells that have suffered DNA damage. Mutations in this gene are associated with ectodermal dysplasia, and cleft lip/palate syndrome 3 (EEC3) ; split-hand/foot malformation 4 (SHFM4) ; ankyloblepharon-ectodermal defects-cleft lip/palate; ADμLT syndrome (acro-dermato-ungual-lacrim