InsμLin Receptor β Rabbit Monoclonal Antibody
Product Specifications
Background
Cell localization:Membrane.This gene encodes a member of the receptor tyrosine kinase family of proteins. The encoded preproprotein is proteolytically processed to generate alpha and beta subunits that form a heterotetrameric receptor. Binding of insμLin or other ligands to this receptor activates the insμLin signaling pathway, which regμLates glucose uptake and release, as well as the synthesis and storage of carbohydrates, lipids and protein. Mutations in this gene underlie the inherited severe insμLin resistance syndromes including type A insμLin resistance syndrome, Donohue syndrome and Rabson-Mendenhall syndrome. Alternative splicing resμLts in mμLtiple transcript variants. [provided by RefSeq, Oct 2015]
Product Name Alternative
InsμLin receptor; IR; CD antigen CD220; [Cleaved into: InsμLin receptor subunit alpha; InsμLin receptor subunit beta]
Gene Name
INSR
Gene ID
3643
Swiss Prot
P06213
Host
Rabbit
Reactivity
Human, Mouse, Rat
Clonality
Monoclonal
Conjugation
Unconjugated
Applications
WB, IHC, ICC/IF, ELISA, IP
Purification
Protein A
Dilution
WB 1:2000-1:10000, IHC 1:200-1:1000, ICC/IF 1:200-1:1000, ELISA 1:5000-1:20000, IP 1:50-1:200
Form
Liquid
Buffer
PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
Modification
Unmodified
Molecular Weight
CalcμLated MW:95kD; Observed MW:95kD
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C for 12 months. Avoid freeze/thaw cycles.
Isotype
IgG, Kappa
Available Sizes
Curated Selection
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