CENP-A Rabbit Monoclonal Antibody

Cell localization:Nucleus . Chromosome, centromere, kinetochore . Chromosome, centromere . Localizes exclusively in the kinetochore domain of centromeres. Occupies a compact domain at the inner kinetochore plate stretching across 2 thirds of the length of the constriction but encompassing only one third of the constriction width and height (PubMed:19114591) . Phosphorylation at Ser-68 during early mitosis abolishes association with chromatin and centromeres and resμLts in dispersed nuclear location (PubMed:25556658) . ..Centromeres are the differentiated chromosomal domains that specify the mitotic behavior of chromosomes. This gene encodes a centromere protein which contains a histone H3 related histone fold domain that is required for targeting to the centromere. Centromere protein A is proposed to be a component of a modified nucleosome or nucleosome-like structure in which it replaces 1 or both copies of conventional histone H3 in the (H3-H4) 2 tetrameric core of the nucleosome particle. The protein is a replication-independent histone that is a member of the histone H3 family. Alternative splicing resμLts in mμLtiple transcript variants encoding distinct isoforms. [provided by RefSeq, Nov 2015]