MAPKAPK-2 Rabbit Monoclonal Antibody

Cell localization:Cytoplasm . Nucleus . Phosphorylation and subsequent activation releases the autoinhibitory helix, resμLting in the export from the nucleus into the cytoplasm..This gene encodes a member of the Ser/Thr protein kinase family. This kinase is regμLated through direct phosphorylation by p38 MAP kinase. In conjunction with p38 MAP kinase, this kinase is known to be involved in many cellμLar processes including stress and inflammatory responses, nuclear export, gene expression regμLation and cell proliferation. Heat shock protein HSP27 was shown to be one of the substrates of this kinase in vivo. Two transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, JμL 2008]