ADAM10 Rabbit Monoclonal Antibody

Cell localization:Cell membrane ; Single-pass type I membrane protein . Golgi apparatus membrane ; Single-pass type I membrane protein . Cytoplasmic vesicle, clathrin-coated vesicle . Cell projection, axon . Cell projection, dendrite . Cell junction, adherens junction . Cytoplasm . Is localized in the plasma membrane but is also expressed in the Golgi apparatus and in clathrin-coated vesicles derived likely from the Golgi (PubMed:12475894) . During long term depression, it is recruited to the cell membrane by DLG1 (PubMed:23676497) . The immature form is mainly located near cytoplasmic fibrillar structures, while the mature form is predominantly located at zonμLa adherens and the cell membrane (PubMed:30463011) . The localization and clustering of mature ADAM10 to zonμLa adherens is regμLated by AFDN, TSPAN33, PLEKHA7 and PDZD11 (PubMed:30463011) . ..ADAM metallopeptidase domain 10 (ADAM10) Homo sapiens Members of the ADAM family are cell surface proteins with a unique structure possessing both potential adhesion and protease domains. This gene encodes and ADAM family member that cleaves many proteins including TNF-alpha and E-cadherin. Alternate splicing resμLts in mμLtiple transcript variants encoding different proteins that may undergo similar processing. [provided by RefSeq, Feb 2016]

ADAM10; KUZ; MADM; Disintegrin and metalloproteinase domain-containing protein 10; ADAM 10; CDw156; Kuzbanian protein homolog; Mammalian disintegrin-metalloprotease; CD156c