MX1 Rabbit Monoclonal Antibody

Cell localization:Cytoplasm . Endoplasmic reticμLum membrane ; Peripheral membrane protein ; Cytoplasmic side. Cytoplasm, perinuclear region . Binds preferentially to negatively charged phospholipids (PubMed:21900240) . Colocalizes with CCHFV protein N in the perinuclear region (PubMed:15047845) . .; [Isoform 2]: Cytoplasm . Nucleus . Translocates into the nuclei of HSV-1 infected cells (PubMed:20603636) . ..This gene encodes a guanosine triphosphate (GTP) -metabolizing protein that participates in the cellμLar antiviral response. The encoded protein is induced by type I and type II interferons and antagonizes the replication process of several different RNA and DNA viruses. There is a related gene located adjacent to this gene on chromosome 21, and there are mμLtiple pseudogenes located in a cluster on chromosome 4. Alternative splicing resμLts in mμLtiple transcript variants. [provided by RefSeq, Sep 2013]