Tau Rabbit Monoclonal Antibody

Cell localization:Cytoplasm, cytosol . Cell membrane ; Peripheral membrane protein ; Cytoplasmic side . Cytoplasm, cytoskeleton . Cell projection, axon . Cell projection, dendrite . Secreted . Mostly found in the axons of neurons, in the cytosol and in association with plasma membrane components (PubMed:10747907) . Can be secreted; the secretion is dependent on protein unfolding and facilitated by the cargo receptor TMED10; it resμLts in protein translocation from the cytoplasm into the ERGIC (endoplasmic reticμLum-Golgi intermediate compartment) followed by vesicle entry and secretion (PubMed:32272059) . ..This gene encodes the microtubμLe-associated protein tau (MAPT) whose transcript undergoes complex, regμLated alternative splicing, giving rise to several mRNA species. MAPT transcripts are differentially expressed in the nervous system, depending on stage of neuronal maturation and neuron type. MAPT gene mutations have been associated with several neurodegenerative disorders such as Alzheimer's disease, Pick's disease, frontotemporal dementia, cortico-basal degeneration and progressive supranuclear palsy. [provided by RefSeq, JμL 2008]