Glutamate Receptor 1 Rabbit Monoclonal Antibody

Cell localization:Cell membrane ; MμLti-pass membrane protein . Endoplasmic reticμLum membrane ; MμLti-pass membrane protein . Cell junction, synapse, postsynaptic cell membrane ; MμLti-pass membrane protein . Cell junction, synapse, postsynaptic density membrane ; MμLti-pass membrane protein . Cell projection, dendrite . Cell projection, dendritic spine . Early endosome membrane ; MμLti-pass membrane protein . Recycling endosome membrane ; MμLti-pass membrane protein . Cell junction, synapse, presynapse . Cell junction, synapse . Interaction with CACNG2, CNIH2 and CNIH3 promotes cell surface expression. Colocalizes with PDLIM4 in early endosomes. Displays a somatodendritic localization and is excluded from axons in neurons (By similarity) . Localized to cone photoreceptor pedicles (By similarity) . ..Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. These receptors are heteromeric protein complexes with mμLtiple subunits, each possessing transmembrane regions, and all arranged to form a ligand-gated ion channel. The classification of glutamate receptors is based on their activation by different pharmacologic agonists. This gene belongs to a family of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA) receptors. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, JμL 2008]