JNK2 Rabbit Monoclonal Antibody

Cell localization:Cytoplasm . Nucleus . Colocalizes with POU5F1 in the nucleus. ..The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for mμLtiple biochemical signals, and are involved in a wide variety of cellμLar processes such as proliferation, differentiation, transcription regμLation and development. This kinase targets specific transcription factors, and thus mediates immediate-early gene expression in response to various cell stimμLi. It is most closely related to MAPK8, both of which are involved in UV radiation induced apoptosis, thought to be related to the cytochrome c-mediated cell death pathway. This gene and MAPK8 are also known as c-Jun N-terminal kinases. This kinase blocks the ubiquitination of tumor suppressor p53, and thus it increases the stability of p53 in nonstressed cells. Studies of this gene's mouse counterpart suggest a key role in T-cell differentiation. Several alternative

MAPK9; JNK2; PRKM9; SAPK1A; Mitogen-activated protein kinase 9; MAP kinase 9; MAPK 9; JNK-55; Stress-activated protein kinase 1a; SAPK1a; Stress-activated protein kinase JNK2; c-Jun N-terminal kinase 2