TRIM29 (18R2) Rabbit Monoclonal Antibody
Product Specifications
Background
It is able to complement the radiosensitivity defect of an ataxia telangiectasia (AT) fibroblast cell line. Plays a crucial role in the regulation of macrophage activation in response to viral or bacterial infections within the respiratory tract. Mechanistically, TRIM29 interacts with IKBKG/NEMO in the lysosome where it induces its 'Lys-48' ubiquitination and subsequent degradation. In turn, the expression of type I interferons and the production of proinflammatory cytokines are inhibited. Additionally, induces the 'Lys-48' ubiquitination of STING1 in a similar way, leading to its degradation.
Product Name Alternative
ATDC; TRIM29
Gene Name
TRIM29
Gene ID
23650
Swiss Prot
Q14134
Host
Rabbit
Reactivity
Human, Mouse, Rat
Clonality
Monoclonal
Conjugation
Unconjugated
Applications
WB
Purification
Affinity purification
Dilution
WB 1:1000-1:5000
Form
Liquid
Buffer
Supplied in 50mM Tris-Glycine (pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% New type preservative N and 0.05% BSA.
Modification
Unmodified
Molecular Weight
66kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C for 12 months. Avoid freeze/thaw cycles.
Isotype
IgG
Available Sizes
Curated Selection
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