MMP8 (4B14) Rabbit Monoclonal Antibody
Product Specifications
Background
Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. However, the enzyme encoded by this gene is stored in secondary granules within neutrophils and is activated by autolytic cleavage. Its function is degradation of type I, II and III collagens. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3. Can degrade fibrillar type I, II, and III collagens.
Product Name Alternative
HNC; CLG1; MMP-8; PMNL-CL; COLLAGENASE I; NEUTROPHIL; matrix metalloproteinase 8
Gene Name
MMP8
Gene ID
4317
Swiss Prot
P22894
Host
Rabbit
Reactivity
Human, Mouse, Rat
Clonality
Monoclonal
Conjugation
Unconjugated
Applications
WB, IHC, IP, IF-P
Purification
Affinity purification
Dilution
WB 1:1000-1:5000, IHC 1:100-1:200, IP 1:50-1:100, IF-P 1:100-1:200
Form
Liquid
Buffer
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% New type preservative N and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.
Modification
Unmodified
Molecular Weight
53kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C for 12 months. Avoid freeze/thaw cycles.
Isotype
IgG
Available Sizes
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