KLF4 (11U14) Rabbit Monoclonal Antibody
Product Specifications
Background
KLF4 is a member of the erythroid Kruppel-like factor (EKLF) multigene family that is highly expressed in the differentiating layers of the epidermis. KLF4 plays a critical role in the differentiation of epithelial cells and is essential for normal gastric homeostasis and function as both a repressor and activator of transcription. Transcription factor; can act both as activator and as repressor. Binds the 5'-CACCC-3' core sequence. Binds to the promoter region of its own gene and can activate its own transcription. Regulates the expression of key transcription factors during embryonic development. Plays an important role in maintaining embryonic stem cells, and in preventing their differentiation. Required for establishing the barrier function of the skin and for postnatal maturation and maintenance of the ocular surface. Involved in the differentiation of epithelial cells and may also function in skeletal and kidney development. Contributes to the down-regulation of p53/TP53 transcription.
Product Name Alternative
Krueppel-like factor 4; KLF4; EZF; GKLF
Gene Name
KLF4
Gene ID
9314
Swiss Prot
O43474
Host
Rabbit
Reactivity
Human
Clonality
Monoclonal
Conjugation
Unconjugated
Applications
WB, IHC, ICC/IF, FC
Purification
Affinity purification
Dilution
WB 1:500-1:2000, IHC 1:100-1:200, ICC/IF 1:100-1:200, FC 1:20-1:50
Form
Liquid
Buffer
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% New type preservative N and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.
Modification
Unmodified
Molecular Weight
55kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C for 12 months. Avoid freeze/thaw cycles.
Product Datasheet
https://assets.enkilife.com/files/antibody/AMRe13061_Enkilife_EN.pdf
Isotype
IgG
Available Sizes
Curated Selection
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