Bcl-XL (4B16) Rabbit Monoclonal Antibody

Product Specifications

Background

The protein encoded by this gene belongs to the BCL-2 protein family. BCL-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. Potent inhibitor of cell death. Inhibits activation of caspases. Appears to regulate cell death by blocking the voltage- dependent anion channel (VDAC) by binding to it and preventing the release of the caspase activator, CYC1, from the mitochondrial membrane. Also acts as a regulator of G2 checkpoint and progression to cytokinesis during mitosis. Isoform Bcl-X (S) promotes apoptosis.

Product Name Alternative

Apoptosis regulator Bcl-X; BLC2L; Bcl-2-like 1 protein bclxl; BCL2L; BCL2L1; BCLX

Gene Name

BCL2L1

Gene ID

598

Swiss Prot

Q07817

Host

Rabbit

Reactivity

Human, Mouse, Rat

Clonality

Monoclonal

Conjugation

Unconjugated

Applications

WB, IHC, ICC/IF, FC, IP

Purification

Affinity purification

Dilution

WB 1:500-1:2000, IHC 1:200-1:2000, ICC/IF 1:100-1:500, FC 1:20-1:100, IP 1:10-1:50

Form

Liquid

Buffer

Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% New type preservative N and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.