MUM1 (9F19) Rabbit Monoclonal Antibody

Product Specifications

Background

Melanoma associated antigen (mutated) 1 (MUM1, EXPAND1) is a PWWP-domain containing chromatin binding protein involved in maintaining chromatin architecture of interphase chromosomes. Transcriptional activator. Binds to the interferon-stimulated response element (ISRE) of the MHC class I promoter. Binds the immunoglobulin lambda light chain enhancer, together with PU.1. Probably plays a role in ISRE-targeted signal transduction mechanisms specific to lymphoid cells. Involved in CD8 (+) dendritic cell differentiation by forming a complex with the BATF-JUNB heterodimer in immune cells, leading to recognition of AICE sequence (5'-TGAnTCA/GAAA- 3'), an immune-specific regulatory element, followed by cooperative binding of BATF and IRF4 and activation of genes (By similarity) .

Product Name Alternative

LSIRF; Multiple myeloma oncogene 1; NF-EM5; IRF4; MUM1; Transcriptional activator PIP

Gene Name

IRF4

Gene ID

3662

Swiss Prot

Q15306

Host

Rabbit

Reactivity

Human

Clonality

Monoclonal

Conjugation

Unconjugated

Applications

WB, IHC, ICC/IF, FC, IP

Purification

Affinity purification

Dilution

WB 1:2000-1:20000, IHC 1:200-1:500, ICC/IF 1:200-1:500, FC 1:100-1:1000, IP 1:100-1:500

Form

Liquid

Buffer

Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% New type preservative N and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.