RAGE Rabbit Monoclonal Antibody
Product Specifications
Background
The receptor for advanced glycation end products (RAGE) is member of the immunoglobulin (Ig) superfamily. Mediates interactions of advanced glycosylation end products (AGE) . Binding of AGEs to RAGE results in the induction of cellular oxidant stress and activation of the transcription factor NFkB. Evidence suggests that the induction of oxidant stress results in the activation of an intracellular cascade involving p21 ras and MAP kinase, which leads to activation of transcription.
Product Name Alternative
AGER; RAGE; Advanced glycosylation end product-specific receptor; Receptor for advanced glycosylation end products
Gene Name
AGER
Gene ID
177
Swiss Prot
Q15109
Host
Rabbit
Reactivity
Mouse
Clonality
Monoclonal
Conjugation
Unconjugated
Applications
WB
Field of Research
Neuroscience
Purification
Affinity Purification
Dilution
WB 1:500-1:1000
Form
Liquid
Buffer
50mM Tris-Glycine (pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA
Modification
Unmodified
Molecular Weight
Calculated MW: 43 kDa; Observed MW: 55 kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C for 12 months. Avoid freeze/thaw cycles.
Isotype
IgG
Available Sizes
Curated Selection
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