5'-Methylthioadenosine

5'-Methylthioadenosine (5'- (Methylthio) -5'-deoxyadenosine) is a nucleoside generated from S-adenosylmethionine (SAM) during polyamine synthesis[1]. 5'-Methylthioadenosine suppresses tumors by inhibiting tumor cell proliferation, invasion, and the induction of apoptosis while controlling the inflammatory micro-environments of tumor tissue. 5'-Methylthioadenosine and its associated materials have striking regulatory effects on tumorigenesis[2].

Product Specifications

CAS Number

[2457-80-9]

Product Name Alternative

5'- (Methylthio) -5'-deoxyadenosine; 5'-Deoxy-5'- (methylthio) adenosine; 5'-S-Methyl-5'-thioadenosine

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Apoptosis; Endogenous Metabolite; Parasite

Type

Natural Products

Related Pathways

Anti-infection; Apoptosis; Metabolic Enzyme/Protease

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Cancer; Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/5_acute_-_Methylthio_adenosine.html

Purity

99.71

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

NC1=NC=NC2=C1N=CN2[C@H]3[C@H](O)[C@H](O)[C@@H](CSC)O3

Molecular Formula

C11H15N5O3S

Molecular Weight

297.34

Precautions

H302, H315, H319, H335

References & Citations

[1]Tang Y, et al. 5'-Methylthioadenosine attenuates ischemia reperfusion injury after liver transplantation in rats. Inflammation. 2014;37 (5) :1366-1373.|[2]Li Y, et al. 5'-Methylthioadenosine and Cancer: old molecules, new understanding. J Cancer. 2019;10 (4) :927-936.|[3]Tang B, et al. Specific Targeting of MTAP-Deleted Tumors with a Combination of 2'-Fluoroadenine and 5'-Methylthioadenosine. Cancer Res. 2018;78 (15) :4386-4395.|[4]Yaofeng Li, et al. 5'-Methylthioadenosine and Cancer: old molecules, new understanding. J Cancer. 2019;10 (4) :927-936.