Argonaute 2 Rabbit Monoclonal Antibody
Product Specifications
Background
Required for RNA-mediated gene silencing (RNAi) by the RNA-induced silencing complex (RISC) . Can also upregulate the translation of specific mRNAs under certain growth conditions. Binds to the AU element of the 3'-UTR of the TNF (TNF-alpha) mRNA and upregulates translation under conditions of serum starvation. Also required for transcriptional gene silencing (TGS), in which short RNAs known as antigene RNAs or agRNAs direct the transcriptional repression of complementary promoter regions.
Product Name Alternative
Ago 2; Argonaute 2; dAgo2; eIF2C 2; hAgo2; PPD
Gene Name
AGO2
Gene ID
27161
Swiss Prot
Q9UKV8
Host
Rabbit
Reactivity
Human
Clonality
Monoclonal
Conjugation
Unconjugated
Applications
WB, ICC/IF, IP
Field of Research
Epigenetics and Nuclear Signaling
Purification
Affinity Purification
Dilution
WB 1:500-1:1000, ICC/IF 1:50-1:200, IP 1:20-1:50
Form
Liquid
Buffer
50mM Tris-Glycine (pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA
Modification
Unmodified
Molecular Weight
Calculated MW: 97 kDa; Observed MW: 97 kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C for 12 months. Avoid freeze/thaw cycles.
Isotype
IgG
Available Sizes
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