QK1 Rabbit Monoclonal Antibody
Product Specifications
Background
RNA-binding protein that plays a central role in myelinization (PubMed:16641098) . Binds to the 5'-NACUAAY-N (1,20) -UAAY-3' RNA core sequence. Regulates target mRNA stability (PubMed:23630077) . In addition, acts by regulating pre-mRNA splicing, mRNA export and protein translation. Required to protect and promote stability of mRNAs such as MBP and CDKN1B. Regulator of oligodendrocyte differentiation and maturation in the brain that may play a role in myelin and oligodendrocyte dysfunction in schizophrenia (PubMed:16641098) . Participates in mRNA transport by regulating the nuclear export of MBP mRNA. Also involved in regulation of mRNA splicing of MAG pre-mRNA. Acts as a translational repressor .
Product Name Alternative
QK; Hqk; QK1; QK3; hqkI
Gene Name
QKI
Gene ID
9444
Swiss Prot
Q96PU8
Host
Rabbit
Reactivity
Human, Mouse, Rat
Clonality
Monoclonal
Conjugation
Unconjugated
Applications
WB, IP
Field of Research
Neuroscience
Purification
Affinity Purification
Dilution
WB 1:500-1:1000, IP 1:20-1:50
Form
Liquid
Buffer
50mM Tris-Glycine (pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA
Modification
Unmodified
Molecular Weight
Calculated MW: 38 kDa; Observed MW: 38 kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C for 12 months. Avoid freeze/thaw cycles.
Isotype
IgG
Available Sizes
Curated Selection
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