GNA13 Rabbit Monoclonal Antibody
Product Specifications
Background
Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems (PubMed:15240885, PubMed:16787920, PubMed:16705036, PubMed:27084452) . Activates effector molecule RhoA by binding and activating RhoGEFs (ARHGEF1/p115RhoGEF, ARHGEF11/PDZ-RhoGEF and ARHGEF12/LARG) (PubMed:15240885, PubMed:12515866) . GNA13-dependent Rho signaling subsequently regulates transcription factor AP-1 (activating protein-1) . Promotes tumor cell invasion and metastasis by activating RhoA/ROCK signaling pathway (PubMed:16787920, PubMed:16705036, PubMed:27084452) . Inhibits CDH1-mediated cell adhesion in process independent from Rho activation (PubMed:11976333) .
Product Name Alternative
Guanine nucleotide binding protein (G protein) ; alpha 13; G13
Gene Name
GNA13
Gene ID
10672
Swiss Prot
Q14344
Host
Rabbit
Reactivity
Human
Clonality
Monoclonal
Conjugation
Unconjugated
Applications
WB, IHC
Field of Research
Signal Transduction
Purification
Affinity Purification
Dilution
WB 1:500-1:1000, IHC 1:50-1:100
Form
Liquid
Buffer
50mM Tris-Glycine (pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA
Modification
Unmodified
Molecular Weight
Calculated MW: 44 kDa; Observed MW: 44 kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C for 12 months. Avoid freeze/thaw cycles.
Isotype
IgG
Available Sizes
Frequently Asked Questions
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