BUBR1 Rabbit Monoclonal Antibody

Product Specifications

Background

Essential component of the mitotic checkpoint. Required for normal mitosis progression. The mitotic checkpoint delays anaphase until all chromosomes are properly attached to the mitotic spindle. One of its checkpoint functions is to inhibit the activity of the anaphase-promoting complex/cyclosome (APC/C) by blocking the binding of CDC20 to APC/C, independently of its kinase activity. The other is to monitor kinetochore activities that depend on the kinetochore motor CENPE. Required for kinetochore localization of CENPE.

Product Name Alternative

BUB1B; BUBR1; MAD3L; SSK1; Mitotic checkpoint serine/threonine-protein kinase BUB1 beta; MAD3/BUB1-related protein kinase; hBUBR1; Mitotic checkpoint kinase MAD3L; Protein SSK1

Gene Name

BUB1B

Gene ID

701

Swiss Prot

O60566

Host

Rabbit

Reactivity

Human, Hamster

Clonality

Monoclonal

Conjugation

Unconjugated

Applications

WB, IHC, IP

Field of Research

Cell Biology

Purification

Affinity Purification

Dilution

WB 1:500-1:1000, IHC 1:50-1:100, IP 1:20-1:50

Form

Liquid

Buffer

50mM Tris-Glycine (pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA

Modification

Unmodified

Molecular Weight

Calculated MW: 120 kDa; Observed MW: 120 kDa

Storage Conditions

Store at 4°C short term. Aliquot and store at -20°C for 12 months. Avoid freeze/thaw cycles.

Isotype

IgG

Available Sizes

Curated Selection

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239367-02 250 mg

L-Phenylalanine 7-amido-4-methylcoumarin trifluoroacetate 98+% (HPLC)

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