NUMB Rabbit Monoclonal antibody

Product Specifications

Background

Numb acts as a negative regulator of Notch signaling by promoting ubiquitination and degradation of Notch. The protein is asymmetrically segregated into one daughter cell during cell division, producing two daughter cells with different responses to Notch signaling and different cell fates. The localization of Numb can also be regulated by G-protein coupled receptor (GPCR) and PKC signaling.

Product Name Alternative

NUMB; Protein numb homolog; h-Numb; Protein S171

Gene Name

NUMB

Gene ID

8650

Swiss Prot

P49757

Host

Rabbit

Reactivity

Human, Mouse, Rat

Clonality

Monoclonal

Conjugation

Unconjugated

Applications

WB, IHC, IP

Field of Research

Neuroscience

Purification

Affinity Purified

Dilution

WB 1:500-1:1000, IHC 1:50-1:100, IP 1:20-1:50

Form

Liquid

Buffer

50mM Tris-Glycine (pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA

Modification

Unmodified

Molecular Weight

Calculated MW: 71 kDa; Observed MW: 71 kDa

Storage Conditions

Store at 4°C short term. Aliquot and store at -20°C for 12 months. Avoid freeze/thaw cycles.

Isotype

IgG

Available Sizes

Curated Selection

Explore Other Products

Discover premium biology products from our extensive collection of 20M+ items

546984 200 µL

Fusion (FITC)

Ask

View Details

NBP2-90391B 0.1 mL

Rabbit Monoclonal CXCL2/GRO beta/MIP-2/CINC-3 Antibody (019) [Biotin]

Ask

View Details

430853 5/pk

RB,1700CM,EASY GRIP,PS,S,BK,5/40

Ask

View Details

244312-ML490 100 µL

CCL2 (Chemokine (C-C Motif) Ligand 2, GDCF-2, HC11, HSMCR30, MCAF, MCP-1, MCP1, MGC9434, SCYA2, SMC-CF) (MaxLight 490)

Ask

View Details