Phospho-Rb (Thr252) Rabbit Monoclonal antibody
Product Specifications
Background
Cell cycle-dependent phosphorylation by a CDK inhibits Rb target binding and allows cell cycle progression. Rb inactivation and subsequent cell cycle progression likely requires an initial phosphorylation by cyclin D-CDK4/6 followed by cyclin E-CDK2 phosphorylation. Specificity of different CDK/cyclin complexes has been observed in vitro and cyclin D1 is required for Ser780 phosphorylation in vivo.
Product Name Alternative
RB1; Retinoblastoma-associated protein; p105-Rb; pRb; Rb; pp110
Gene Name
RB1
Gene ID
5925
Swiss Prot
P06400
Host
Rabbit
Reactivity
Human, Rat
Clonality
Monoclonal
Conjugation
Unconjugated
Applications
WB, IHC
Field of Research
Cell Biology
Purification
Affinity Purified
Dilution
WB 1:500-1:1000, IHC 1:50-1:100
Form
Liquid
Buffer
50mM Tris-Glycine (pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA
Modification
Phosphorylated
Molecular Weight
Calculated MW: 106 kDa; Observed MW: 110 kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C for 12 months. Avoid freeze/thaw cycles.
Isotype
IgG
Available Sizes
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