Recombinant Mouse CD6 (C-6His)

CD6 is a member of the group B scavenger receptor cysteinerich (SRCR) superfamily. CD6 is a type I membrane glycoprotein and contains three extracellular SRCR domains. CD6 is expressed at low levels on immature thymocytes and at high levels on mature thymocytes. The majority of peripheral blood T cells, a subset of B cells, and a subset of neuronal cells express CD6. Mouse CD6 is a 626 amino acid (aa) protein with a 24 aa sequence, a 372 aa extracellular domain, and a 204 aa cytoplasmic region. The role of CD6 has not been fully elucidated. However, it appears to play a role as both a costimulatory molecule in T cell activation and as an adhesion receptor.CD6/ALCAM interactions have been postulated to play a role in thymocyte development. The CD6 intracellular domain contains regions that can interact with SH2 or SH3 containing proteins. However, the signaling pathways have not been elucidated.

Always centrifuge tubes before opening.Do not mix by vortex or pipetting.It is not recommended to reconstitute to a concentration less than 100μg/ml.Dissolve the lyophilized protein in distilled water.Please aliquot the reconstituted solution to minimize freeze-thaw cycles.

Store at -70°C/-20°C, stable for 6 months after receipt.Store at ≤-70°C, stable for 3 months under sterile conditions after opening. Please minimize freeze-thaw cycles.

Recombinant Mouse CD6 Antigen is produced by our Mammalian expression system and the target gene encoding Leu18-Gly396 is expressed with a 6His tag at the C-terminus.