Recombinant Human GIPR N-ECD (C-Fc)
Product Specifications
Background
GIP receptor (GIPR) belongs to the G-protein coupled receptor family, activating adenylate cyclase and increasing levels of intracellular cyclic adenosine monophosphate (cAMP) in pancreatic b cells, thereby stimulating insulin section glucosedependently. New discoveries of GIP receptor (GIPR) biology in adipose tissue, as well as findings that co-agonists for the glucagon-like peptide-1 receptor (GLP-1R) and GIPR induce greater weight loss than that seen with GLP-1R agonists alone, has led to continued interest in manipulating GIPR activity for the treatment of obesity/type 2 diabetes mellitus (T2DM) .
Product Name Alternative
Gastric inhibitory polypeptide receptor; GIP-R; Glucose-dependent insulinotropic polypeptide receptor; GIPR
Accession Number
P48546
Host
Human Cells
Endotoxin
<1 EU/µg as determined by LAL test.
Purity
Greater than 95% as determined by reducing SDS-PAGE
Form
Liquid
Molecular Weight
40.3 kDa
Shipping Conditions
The product is shipped on dry ice/polar packs. Upon receipt, store it immediately at the temperature listed below.
Storage Conditions
Store at -70°C/-20°C, stable for 6 months after receipt.Store at ≤-70°C, stable for 3 months under sterile conditions after opening. Please minimize freeze-thaw cycles.
Formulation
Supplied as a 0.2 μm filtered solution of PBS, pH7.4.
Construct
Recombinant Human Gastric inhibitory polypeptide receptor is produced by our Mammalian expression system and the target gene encoding Arg22-Gln138 is expressed with a human IgG1 Fc tag at the C-terminus.
Species
Human
Available Sizes
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