Recombinant Human DLL3 (353-492, C-6His)

Product Specifications

Background

Delta-like protein 3 (DLL3) is a transmembrane protein that belongs to the Delta/Serrate/Lag-2 (DSL) family of Notch ligands. DLL3 is highly expressed in tumor cells and could be involved in the modification of tumor (immune) microenvironment. Neuroendocrine carcinomas are very aggressive tumors with few treatment options. DLL3 seems to be an optimal target for therapeutic intervention, as it is expressed mainly on the membrane of tumor cells with neuroendocrine origin.

Product Name Alternative

Delta-like protein 3; Drosophila Delta homolog 3; Delta3; DLL3

Accession Number

Q9NYJ7

Host

Human Cells

Endotoxin

<1 EU/µg as determined by LAL test.

Purity

Greater than 95% as determined by reducing SDS-PAGE

Form

Liquid

Molecular Weight

15.4 KDa

Shipping Conditions

The product is shipped on dry ice/polar packs. Upon receipt, store it immediately at the temperature listed below.

Storage Conditions

Store at -70°C/-20°C, stable for 6 months after receipt.Store at ≤-70°C, stable for 3 months under sterile conditions after opening. Please minimize freeze-thaw cycles.

Formulation

Supplied as a 0.2 μm filtered solution of 20mM PB, 100mM NaCl, 8% Sucrose, 20% Glycerol, 0.05% Tween80, pH6.0.

Construct

Recombinant Human Delta-like protein 3 is produced by our Mammalian expression system and the target gene encoding Arg353-Leu492 is expressed with a 6His tag at C-terminus.