What is the catalog number for Recombinant Human BLK (C-6His)?

The catalog number for Recombinant Human BLK (C-6His) is PEH1753.

What sizes are available for Recombinant Human BLK (C-6His)?

Recombinant Human BLK (C-6His) is available in the following size(s): 10 µg, 50 µg, 500 µg.

How many pack sizes does Recombinant Human BLK (C-6His) come in?

Recombinant Human BLK (C-6His) is available in 3 different pack sizes.

Is Recombinant Human BLK (C-6His) in stock?

Recombinant Human BLK (C-6His) is currently made to order / not held in immediate stock. Contact us for lead time.

Are there any special shipping requirements for Recombinant Human BLK (C-6His)?

Recombinant Human BLK (C-6His) is requires dry ice shipping.

Recombinant Human BLK (C-6His)

Product Specifications

Background

Tyrosine-Protein Kinase Blk (BLK) contains one protein kinase domain, one SH2 domain and one SH3 domain. BLK is a non-receptor tyrosine kinase, which is involved in B-lymphocyte development, differentiation and signaling. B-cell receptor (BCR) signaling requires a tight regulation of several protein tyrosine kinases and phosphatases, and associated coreceptors. Signaling through BLK plays an important role in transmitting signals through surface immunoglobulines and supports the pro-B to pre-B transition, as well as the signaling for growth arrest and apoptosis downstream of B-cell receptor. Defects in BLK are a cause of maturity-onset diabetes of the young type 11 (MODY11) .

Product Name Alternative

Tyrosine-Protein Kinase Blk; B Lymphocyte Kinase; p55-Blk; BLK

Accession Number

P51451

Host

E.coli

Endotoxin

<1 EU/µg as determined by LAL test.

Purity

Greater than 95% as determined by reducing SDS-PAGE

Form

Liquid

Molecular Weight

58.8 KDa

Shipping Conditions

The product is shipped on dry ice/polar packs. Upon receipt, store it immediately at the temperature listed below.

Storage Conditions

Store at -70°C/-20°C, stable for 6 months after receipt.Store at ≤-70°C, stable for 3 months under sterile conditions after opening. Please minimize freeze-thaw cycles.

Formulation

Supplied as a 0.2 μm filtered solution of 20mM Tris-HCl, 500mM NaCl, 1mM DTT, pH 7.4.

Construct

Recombinant Human Tyrosine-Protein Kinase BLK is produced by our E.coli expression system and the target gene encoding Gly2-Pro505 is expressed with a 6His tag at the C-terminus.