Recombinant Human MAN1B1 (C-6His)
Product Specifications
Background
Endoplasmic Reticulum Mannosyl-Oligosaccharide 1,2-α-Mannosidase (MAN1B1) belongs to the glycosyl hydrolase 47 family. MAB1B1 is a single-pass type II membrane protein and widely expressed in many tissues. MAB1B1 is involved in glycoprotein quality control targeting of misfolded glycoproteins for degradation. MAB1B1 can be inhibited by both 1-deoxymannojirimycin (dMNJ) and kifunensine. Defects in MAN1B1 are the cause of mental retardation autosomal recessive type 15 (MRT15) . Mental retardation is characterized by significantly below average general intellectual functioning, it is also associated with impairments in adaptative behavior and manifested during the developmental period.
Product Name Alternative
Endoplasmic Reticulum Mannosyl-Oligosaccharide 1; 2-Alpha-Mannosidase; ER Alpha-1; 2-Mannosidase; ER Mannosidase 1; ERMan1; Man9GlcNAc2-Specific-Processing Alpha-Mannosidase; Mannosidase Alpha Class 1B Member 1; MAN1B1
Accession Number
Q9UKM7
Host
Human Cells
Endotoxin
<1 EU/µg as determined by LAL test.
Purity
Greater than 95% as determined by reducing SDS-PAGE
Form
Liquid
Molecular Weight
68.7 KDa
Shipping Conditions
The product is shipped on dry ice/polar packs. Upon receipt, store it immediately at the temperature listed below.
Storage Conditions
Store at -70°C/-20°C, stable for 6 months after receipt.Store at ≤-70°C, stable for 3 months under sterile conditions after opening. Please minimize freeze-thaw cycles.
Product Datasheet
https://assets.enkilife.com/files/Protein/PHH1129_EnkiLife.pdf
Formulation
Supplied as a 0.2 μm filtered solution of 20 mM PB, 50 mM NaCl, 5% Sucrose, 5% Mannitol, 0.05% Tween 80, pH8.0.
Construct
Recombinant Human Endoplasmic Reticulum Mannosyl-Oligosaccharide 1,2-α-Mannosidase/MAN1B1 is produced by our Mammalian expression system and the target gene encoding Asp106-Ala699 is expressed with a 6His tag at the C-terminus.
Species
Human
Available Sizes
Curated Selection
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